Brief Communications Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington’s Disease and Is Manifest in Astrocytes
نویسندگان
چکیده
Marta Valenza,1,2 Valerio Leoni,3* Joanna M. Karasinska,4* Lara Petricca,1,2* Jianjia Fan,5 Jeffrey Carroll,4 Mahmoud A. Pouladi,4 Elisa Fossale,6 Huu Phuc Nguyen,7 Olaf Riess,7 Marcy MacDonald,6 Cheryl Wellington,5 Stefano DiDonato,3 Michael Hayden,4 and Elena Cattaneo1,2 1Department of Pharmacological Sciences and 2Centre for Stem Cell Research, Università degli Studi di Milano, 20133 Milan, Italy, 3Unit of Genetics of Neurodegenerative and Metabolic Diseases, Carlo Besta Neurological Institute, 20133 Milan, Italy, 4Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4, 5Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5, 6Centre for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, and 7Department of Medical Genetics, University of Tübingen, 72016 Tübingen, Germany
منابع مشابه
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes.
Brain cholesterol, which is synthesized locally, is a major component of myelin and cell membranes and participates in neuronal functions, such as membrane trafficking, signal transduction, neurotransmitter release, and synaptogenesis. Here we show that brain cholesterol biosynthesis is reduced in multiple transgenic and knock-in Huntington's disease (HD) rodent models, arguably dependent on de...
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